Unleashing the Potential of Immunogenetics
We empower labs and clinics to make better drugs and improve patient care through a deeper understanding of how the immune system works.
Adaptive Immune Receptor Profiling
Current immune profiling technologies lack the resolution needed to understand the impact of immune system diversity on human health, obscuring associations between immune function and clinical outcomes and impeding development of effective biomarkers, treatments, and prophylactics. Through Clairity, our Adaptive Immune Receptor Profiling platform, Clareo technology makes better data possible.
ClAIRity Technologies
Unmatched Receptor Resolution
The first RNA-based assay for profiling complete immune receptor transcripts
Achieve complete gene coverage and accurate allele discrimination with ProfilAIR, enabling detailed immune receptor profiling.
Genome-Repertoire Integration
The first assay for complete genomic characterization of immune receptor loci
GenotypAIR connects genomic features to biological functions, providing insights into personalized immune responses and clinical outcomes.
We are the first and only provider of immunogenetic assays that allow you to leverage the strengths of long-read sequencing to comprehensively profile antibody and T cell receptor genes at both the transcriptome and genome levels.
Our Specialized Services
Comprehensive Immune Repertoire Profiling
Unlock the full potential of immune receptor analysis using our ProfilAIR technology. Enhance therapeutic precision and improve patient outcomes.
Personalized Immunogenetic Sequencing
Utilize our GenotypeAIR technology to unlock complex connections between an individual’s inherited genetic profile and their immune response.
Custom Bioinformatics Solutions
Tailor-made computational tools designed to meet the unique needs of your research and clinical applications.
Consultative Expertise
Benefit from our expert guidance in designing and implementing immunogenetic studies for impactful results.
Distinctive Features of Our Services
Unmatched Analytical Accuracy
Our methodologies ensure precise and reliable data interpretation, setting new standards in immunogenetic research.
Scalable Solutions
Adapt our services to fit the scale of your project, from small-scale studies to large clinical trials.
Rapid Turnaround Times
Experience expedited processing and delivery of results without compromising quality.
Collaborative Approach
Work closely with our team to integrate our services seamlessly into your existing workflows.
Our Process Explained
Delivering Precision Immune Profiling
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Step 1: Consultation
We begin with a comprehensive consultation to understand your specific needs and objectives, tailoring our approach to suit your unique requirements.
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Step 2: Analysis
Our team conducts in-depth immunogenetic analyses, utilizing cutting-edge technology to uncover critical insights into immune receptor diversity.
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Step 3: Implementation
We deliver actionable strategies and solutions, integrating our findings into your therapeutic development process to enhance outcomes.
Applications in Research and Clinical Settings
Transforming Patient Care with Advanced Immunogenetic Insights
Clareo’s cutting-edge technologies are revolutionizing the way researchers and clinicians approach patient care. By providing comprehensive profiling of immune receptor genes, our solutions enable precise therapeutic development and personalized treatment strategies. Whether in academic research or clinical diagnostics, our platforms offer unparalleled insights into immune function, helping to identify novel biomarkers and improve patient outcomes.
What Our Clients Say
“Clareo’s ProfilAIR technology has been a game-changer for our research team. The depth of data and accuracy provided has allowed us to make significant strides in understanding immune responses.”
Dr. Emily Thompson, Immunologist
“Partnering with Clareo has transformed our approach to clinical diagnostics. Their comprehensive immune profiling has enhanced our ability to tailor treatments to individual patients.”
Dr. Michael Lee, Clinical Researcher
“The insights gained from Clareo’s GenotypAIR platform have been invaluable in our quest to develop more effective immunotherapies. Their technology is truly at the forefront of immunogenetics.”
Dr. Sarah Patel, Biotech Innovator
About Clareo Biosciences
Clareo Biosciences is dedicated to advancing human health through the power of immunogenetics. Our mission is to empower laboratories and clinics with the tools needed to unlock the complexities of the immune system. As pioneers in the field, we offer unique solutions that leverage long-read sequencing to provide a comprehensive view of immune receptor diversity. Our commitment to innovation and excellence drives us to continuously improve our technologies, ensuring that our partners can achieve groundbreaking discoveries and enhance patient care worldwide. At Clareo, we believe that understanding the immune system is key to unlocking new possibilities in medicine.
Discover the Future of Immunogenetics
Contact Clareo Biosciences, Inc. today to explore how our innovative immunogenetic solutions can transform your research and clinical outcomes. Schedule a consultation to learn more about our cutting-edge services and how they can empower your lab or clinic.
Custom Bioinformatics
Sequence variation in V, D, J, and C genes influences antibody and T cell receptor function. In contrast to other providers, our ProfilAIR technology provides complete coverage of these genes in B and T cell transcriptomes.
- Achieve accurate V, D, J, and C allele discrimination, and delineation of 5’ untranslated regions
- Fully resolve clonal lineages and somatic hypermutation
- Resolve subisotype and functional constant domain residues alongside antigen-binding regions
Description of service
Targeted amplification and long-read sequencing of near full-length adaptive immune receptor repertoire transcripts, including all IG and TCR chains and their subisotypes.
Options
- Any or all IG and TCR chains
Deliverables
→ Complete set of pre- and post-processing HiFi read data of IG/TCR transcripts, with sample-level data quality control reports
→ Inferred germline V, D, J, and C genes and alleles
→ Fully curated transcript data:
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- Allele-level annotation of V, D, J, and C genes (using inferred germlines)
- Isotype, subisotype, and C gene allele-level assignment
- Clone assignment
- Annotation of CDRs and FWRs, and 5’ untranslated regions
- Isotype, subisotype, and haplotype-level V, D, and J gene usage profiles
Personalized Immunogenetics
Immune receptor loci are the most diverse regions in the human genome. GenotypAIR is the only method that can unlock complex connections between an individual’s immune receptors and their immune response.
- Gain informed and precise curation of your immune receptor transcript data
- Directly connect genome and repertoire features to biology
- Delineate personalized genetic factors underlying differential disease and clinical outcomes of interest
Description of service
Targeted enrichment and long-read based sequencing of the immunoglobulin (IG) heavy and light chain loci (kappa, lambda) and/or T cell receptor (TR) genomic loci (alpha, beta, delta, gamma).
Options
- IG only
- TR only
- IG + TR
Deliverables
→ Complete set of pre- and post-processing HiFi read data for all targeted IG/TR regions, with sample-level data quality control reports
→ Assembled IG/TR loci with haplotype-level resolution
→ Personalized assemblies and HiFi reads mapped to genome reference
→ Assembly-curated genes and alleles with quality support metrics
→ Locus-wide genotypes, including single nucleotide variants and large structural variants associated with gene deletions, insertions and duplications
Data Analysis and Exploration
Data generated by our platform offers users unique insights into immune receptor repertoire structure and dynamics, and provides the most comprehensive immune receptor genetic profiles on the market. These insights are made possible by our dedicated data analysis pipelines.
Deliverables
→ Receive direct access to your raw and processed data (output from our pipelines) through our analysis portal.
→ Add labels to your samples, e.g. pre-exposure/post-exposure, to allow tailored filtering and analysis.
→ Explore your data through a selection of data filtering, grouping, and plotting features built directly into the portal.
Custom Data Needs?
Project Consultation
Our team has extensive experience in developing and carrying out a wide array of projects in various contexts and species, from early-phase discovery work, to later stage association testing and model development. We are always eager to roll up our sleeves and work collaboratively with you to design your analyses and aid in the interpretation of results.
Consultative projects could include
→ Conduct association testing between expressed repertoire and/or genetic variables and clinical phenotypes/traits of interest.
→ Leverage our extensive in-house database of IG/TR genetic variation to help you design representative study cohorts or explore potential variation related to responses in specific populations.
→ Tailored services in other immunogenetics applications, for example mapping the IG/TR genomic loci in species of interest, and developing custom assays for non-human species.