Harnessing the power of immunogenetics to improve human health.
Clareo Biosciences enables precision therapeutic development based on immune receptor diversity for labs and clinics worldwide.
Understand adaptive immunity. Improve human health.
At Clareo Biosciences, we leverage immune profiling data to help better understand disease pathologies, improve diagnoses, and design more effective treatments and vaccines.
why variation matters
B and T cells are critical to adaptive immunity. For decades we have studied these cells to understand their roles in human disease. But until recently, it wasn’t appreciated that these cells don’t function the same in all of us. Understanding variations is the key to unraveling why some of us get sick, or respond better to particular treatments and vaccines.
Characterizing immune differences
Characterizing adaptive immune receptor repertoires at the DNA and RNA level has the power to illuminate the most critical differences between us.
The Challenge
Current immune profiling technologies lack the resolution needed to fully characterize adaptive immune receptors at the DNA and RNA level.
As a result, links between immune function, disease pathology, and clinical outcomes are rarely reported.
This isn’t because the links aren’t there, it’s because current technologies can’t see them.
The Clareo Solution: Complete and Precise.
Better, more holistic data is the missing link to effectively use immune profiling to understand disease and to characterize individual responses to vaccines and treatments. And better data means data that is both complete and precise.
Complete Immune repertoire sequencing
Immune receptors don’t just do one thing: they have to both interact with antigens in our environment and also signal appropriately to other molecules and cells in our body. Clareo Biosciences is the first company to offer complete repertoire sequencing, allowing characterization of antibody and T cell receptor domains that correspond to both of these critical functions.
linking Personalized Genetics to Receptor function
By complete sequencing of immune receptor genes at the DNA level, we are able to see how genetic variation dictates antibody and T cell receptor function. Our technology is the first to allow for direct links between immune receptor transcript characterization and an individual’s genetic makeup.
Our Technologies
Immune Profiling
ProfilAIR
- Accurate discrimination of antibody and TCR-encoding genes and alleles, offering improved characterization of antigen-associated clonal lineages, binding domains, and somatic hypermutation profiles
- Link effector function and antigen binding domains with resolution of antibody isotype/subisotype and constant domain allelic variation
- Transparent data analysis workflows and deliverables
Immunogenetics
GenotypAIR
- Cost-effective, accurate, and comprehensive characterization of personalized immunogenetic profiles
- High-resolution immune receptor gene curation, with novel gene and allele discovery
- Complete genotyping of functional coding and non-coding single nucleotide variants and large gene insertions and deletions, all of which underlie critical features of circulating disease-relevant antibodies and T cell receptors
Our Vision
In Research
Generate more comprehensive datasets and build more holistic models to illuminate novel factors underlying immune system function.
In Clinical Trials
Design the most effective trial cohorts, mitigate safety concerns, and optimize donor outcomes by accounting for human immunogenetic diversity and donor-level variation in baseline adaptive immune receptor profiles.
In Precision Medicine
Enhance the design and effectiveness of novel drugs and prophylactics by leveraging personalized immunogenetic profile data to predict and optimize responsiveness and limit potential side-effects.
In Animal Model Design
Build better, data-informed animal models and platforms for pre-clinical trials and therapeutic drug discovery campaigns.
Learn more about our services
Clareo offers Immune Profiling and Personalized Immunogenetic services for labs and clinics worldwide.