Antibodies (immunoglobulins (IGs)) and T Cell receptors (TCRs) are critical players in nearly every immune system process. The genes that encode these adaptive immune receptors reside within the most complex regions of vertebrate genomes. While the study of genetic variation within IG and TCR genes began back in the 1980’s, our understanding of their role in fundamental immunological processes remains incomplete. Even in the modern genomics era, few direct links between these genes and disease have been made. But this isn’t because the links aren’t there, they’ve just been overlooked. Until now, we’ve lacked the tools to accurately characterize the full spectrum of (i) genetic diversity at the genomic level and (ii) the most critical sequence features in expressed antibodies and TCRs that underlie their most important functions in immunity. 

Every member of our team has committed their scientific careers to developing cutting-edge molecular methods, analytical tools for data curation and modeling, and holistic approaches to building first-in-class genomic resources and databases for these highly complex and diverse genes. Our commitment stems from the belief that immunogenetic data holds the secrets to decoding many of today’s mysteries in immune-mediated disease. We endeavor to push our emerging technologies to the forefront of the field and empower labs to leverage immunogenomics to inform the development of novel vaccines, therapeutics, and companion diagnostics that can reach and represent the greatest breadth of global populations.